Molecular, Cellular, and Developmental Biology

Mouse Oocytes and Embryos Cryotop-vitrification Using Low Concentrated Solutions: Effects on Meiotic Spindle, Genetic Material Array and Developmental Ability

Production and functional characterization of human insulin-like growth factor 1

Insulin-like growth factor 1 (IGF-1) is a polypeptide hormone produced mainly by the liver in response to the endocrine growth hormone (GH) stimulus. This protein is involved in a wide range of cellular functions, including cellular differentiation, transformation, apoptosis suppression, migration and cell-cycle progression and other metabolic processes. In the current study, human heart cDNA w...

The role of polymorphism of TaqI in Vitamin D receptor gene and risk of ovarian cancer in women of North India

Background & objective: Ovarian cancer mortality is associated with lower regional sunlight exposure. Vitamin D and its metabolites are best known for their action in calcium and bone metabolism. However, epidemiological studies have suggested that an increased ovarian cancer risk is associated with decreased production of vitamin D. The vitamin D signaling pathway is involved in a wide variety...

Analysis of Promyelocytic Leukemia in Human Embryonic Carcinoma Stem Cells During Retinoic Acid-Induced Neural Differentiation

Background: Promyelocytic leukemia protein (PML) is a tumor suppressor protein that is involved in myeloid cell differentiation in response to retinoic acid (RA). In addition, RA acts as a natural morphogen in neural development. Objectives: This study aimed to examine PML gene expression in different stages of in vitro neural differentiation of NT2 cells, and to investigate the possible role o...

I-5: Fifteen Years after Dolly: The Perspectives on Cellular Reprogramming

s:1202:"It is a truly amazing time to developmental biology. During recent decades, three important breakthroughs have been developed: (i) isolation of stem cells from embryo, (ii) animal cloning by nuclear transfer (NT), and (iii) and induced pluripotent stem cells (iPS). Considering these three approaches of "Cellular Reprogramming", it seems that the required elements for cell therapy now ex...

Investigation the effect of copper nanoparticles on the toxicity and migration of keratinocyte cells

Background: Re-epithelialization has an important role in skin wound healing. Delays in re-epithelialization are more likely to create the chronic wound. Impaired wound healing leads to a large burden of morbidity and mortality. Current treatments based on the use of autografts, allografts and xenografts, suffer from limitations such as, quantity of donor skin available, donor-site infection, p...